The impact of moderate and severe asthma exacerbations on quality of life: a post hoc analysis of randomised controlled trial data

Abstract Background This paper reports the duration of moderate and severe exacerbations in patients with house dust mite induced allergic asthma impact on patients’ quality life. Methods Post-hoc analyses were conducted using data collected during a phase III multi-national trial (MT-04) that investigated time to or exacerbation among 485 withdrawal from inhaled corticosteroids. Patient diaries analysed ascertain exacerbations. The life was measured by calculating utilities for five health states EuroQol-5 Dimension (EQ-5D-3L) Asthma Quality Life Questionnaire (AQL-5D). A regression analysis predicted disutility moving ‘well controlled asthma’ other four states: ‘partially asthma’, ‘uncontrolled ‘moderate exacerbation’ ‘severe exacerbation’. Results Two hundred experienced Moderate involved statistically significant reductions lung function compared constant peak expiratory flow observed without Lung decline occurred 28 days, decreasing approximately 14 days before an followed return baseline over days. symptoms, use short-acting ?2-agonists, frequency nocturnal awakening all increased, starting 10–14 exacerbation, returned within 10–28 following Compared having ranged ? 0.0834 0.0921 0.114 0.121 (AQL-5D); 0.115 0.163 0.153 0.217 (AQL-5D), depending length observation period. Conclusions extends after event. health-related (HRQoL) continues long their occurrence.